reeler mice การใช้

• Heterozygous reeler mice display lower social dominance in some tests, but other social deficits seen in schizophrenia are absent.
• Tests using the Morris water maze have found that reeler mice do not have the abnormalities in spatial reference memory which are found in patients with schizophrenia.
• Reeler mice also have schizophrenia-like anatomical defects in the frontal cortex, but have few cognitive defects which are associated with that area and found in schizophrenia.
• *In one study, reeler mice were shown to have attenuated methamphetamine-induced hyperlocomotion, which was also reduced by a targeted disruption of reelin activity in wildtype mice.
• Reeler mice in the same study demonstrated a decrease in D1 and D2 receptor-mediated dopaminergic function together with reduced numbers of D1 \ D2 receptors . < ! --
• The " reeler " mouse was described for the first time in 1951 by Histopathological studies in the 1960s revealed that the cerebellum of reeler mice is dramatically decreased in size while the normal laminar organization found in several brain regions is disrupted.